Arginase

Arginase (L-arginine amidinohydrolase, EC 3.5.3.1) is a manganesecontaining enzyme that catalyses the hydrolysis of L-arginine to Lornithine and urea. It is abundantly present in the liver of ureotelic animals, where catalyses the final step in the urea cycle. The deficiency, known as hyperargininemia or arginemia, is hereditary and autosomal recessive. It is characterized by lowered activity of arginase in hepatic cells. Symptoms of the disorder include neurological impairment, dementia, retardation of growth and hyperammonemia. NZYTech`s arginase comprises the recombinant human liver enzyme expressed and purified from a modified Escherichia coli strain. The enzyme is provided in 2.5 M lithium sulphate. The specific activity, at 30 °C, is 390 U/mg protein (measured at pH 8.3, using 50 mM L-arginine as substrate).

Temperature and pH optimum/stability: The optimum ranges of pH and temperature are 10-11 and 25-40 °C, respectively.

Activity: 1950 U/ml

Temperature and pH optimum/stability: The optimum ranges of pH and temperature are 10-11 and 25-40 °C, respectively.