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March 8, 2022
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Post in: Technical Articles, Glycobiology
The CBMomes of cellulolytic bacteria colonizing different ecological niches present distinct carbohydrate specificities
Joana L.A. Brás1, Diana Ribeiro2, M.J. Romão2, A.L. Carvalho2, W. Chai3, Y. Liu3, Ten Feizi3,J.A.M. Prates1,4, L.M.A. Ferreira1,4, Carlos M.G.A. Fontes1,4 & Angelina S. Palma2Background
The energetic constraints posed by anaerobic ecosystems lead to the evolution of remarkable highly efficient supramolecular multi-enzyme complexes of Carbohydrate Active enZymes (CAZymes), termed Cellulosomes (Figure 1).
• Cellulosomal enzymes are often appended to other non-catalytic domains, such as Carbohydrate Binding Modules (CBMs), which participate in pivotal protein:carbohydrate interactions, thus targeting the catalytic module to specific carbohydrate substrates.
• Clostridium thermocellum and Ruminococcus flavefaciens FD-1 are two highly efficient cellulosome producing cellulolytic bacteria that colonize different ecological niches, the soil and the rumen of mammals, respectively
